This review focuses on Zn²⁺ transport processes within exocrine cells and mucosal tissues of the gastrointestinal tract. Attention is directed to what is known about mechanisms of Zn²⁺ transport and management within mucosal cells that are functionally unique in each region. An effort has been made to summarize the effects of zinc deficiency on signature functions within each region. Also identified are promising areas for further investigation of zinc transport and management in the gastrointestinal tract, especially with respect to human pathophysioloy and disease.