The maintenance of normal zinc levels is crucial to a variety of cellular functions, with zinc also shown to be a key mediator of a number of central and peripheral disorders. Within the brain, there is now mounting evidence for a pivotal role for zinc dyshomeostasis in the onset and pathological and symptomatic progression of Alzheimer's disease- the most common form of dementia. In this chapter we will discuss the evidence for a disturbance in zinc levels in both the brain and peripheral compartments in Alzheimer's disease. We will further outline the various cellular targets that may be affected by this and how it may contribute to the pathophysiology of Alzheimer's disease. Finally, we will discuss the notion that zinc dyshomeostasis may represent a therapeutic target for this progressive neurodegenerative disorder.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 firstname.lastname@example.org
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 email@example.com