Zinc is most bioavailable from animal flesh, and red meat is the richest common source. In contrast, foods prepared from cereals, legumes, other seeds, and other plant parts may be rich in indigestible zinc-binding ligands, such as phytate and certain dietary fibers, that suppress zinc bioavailability. Zinc absorption from zinc supplements is modulated over time so that the amount of zinc absorbed does not exceed need. Supplements of calcium, iron and folate are reported to suppress zinc absorption under some circumstances. Treatment of zinc deficiency with zinc is most efficacious when other micronutrient are also available in adequate amounts.