Zinc is an essential trace element. The human body contains 2-3 g of zinc. Since there are no storing systems for zinc in the body, zinc has to be ingested daily and the homeostasis has to be regulated accurately. The recommended daily intake varies between 7-12mg of zinc. The chemical properties of zinc made it to one of the favorite metal ions in biological processes. This results in hundreds of zinc-dependent enzymes and signaling events dependent on zinc. Due to this importance a deficiency in zinc is related to multiple organ dysfunctions. Since zinc deficiency has been described in humans it became more and more obvious that severe zinc deficiency is one of the leading health problems in developing countries and marginal zinc deficiency a common problem in the industrial world. Therefore a detailed knowledge about zinc is necessary to understand dysfunctions in zinc homeostasis and to develop therapies using the biological capacity of this trace element.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 firstname.lastname@example.org
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 email@example.com