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II. Mechanical Loading Effects on Articular Cartilage Matrix Metabolism and Osteoarthritis
Robert Lane Smith
14 - 30
Biomedical and Health Research
Volume 70: Osteoarthritis, Inflammation and Degradation: A Continuum
Abstract

This chapter examines the effects of mechanical loading on cartilage metabolism in explant culture and as isolated chondrocytes in high density monolayer and agarose/scaffold cultures. The mechanical loading effects are defined in terms of the two stress states that arise within cartilage, shear stress and hydrostatic pressure. The paper examines possible signaling pathways that could contribute to transduction of changes in the physical environment of articular chondrocyte to modulation of chondrocyte gene and protein expression.

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