Increasing physician adherence to the clinical practice guidelines (CPG) for infections should improve antibiotic prescription practices. The aim of this study was to present the decision elements of these CPG in an original interface to be implemented in the website “Antibiocarte”. We manually analyzed all CPG available for ambulatory treatment of infections. We extracted all terms related to the antibiotic therapy decisions and grouped them into decision or action variables. We then modeled the antibiotic therapy decision process and designed an interface according to ergonomic principles. The interface consists of five fixed parts: a decision table, two information zones, a zone with the reasons for hospitalization, and a zone with situations not concerned by the CPG. All CPG could be implemented according to this model. The usability of the new interface was evaluated by ten general practitioners using the System Usability Scale (SUS) and found to be satisfactory and appropriate for clinical use.