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Upper gastrointestinal bleeding is considered the most frequent emergency in endoscopy units. Decisive for successful treatment of acute upper gastrointestinal bleeding is a timely recognition. We have developed a telemetric implant containing a novel optical sensor principle able to detect the presence of blood in the lumen of the GI tract. In-vivo experiments demonstrated the possibility to detect bleeding in situ and to send an alert signal to an extracorporeal receiver.