The “evidence-based medicine” (EBM) paradigm is centered on the concept of “best evidence” and clinical studies based on this approach are more likely to be considered by physicians in their practice.

In this paper we describe an ontology representing the concepts involved in evidence-based medicine and meta-analysis and show how an ontological approach can be applied both for revisiting EBM conceptual foundations and for allowing a more effective knowledge-based information retrieval in literature.