Objectives: To model and implement a medical web portal providing access to well qualified and high-quality information. Material and methods: The Unified Medical Language System (UMLS) knowledge sources of the U.S. National Library of Medicine and an Information Sources Catalog (ISC) resulting from the ARIANE project are described The XML technology that allows files transformations by the means of XSLT is briefly presented Results: The design and implementation of software modules that exploit knowledge sources, operate the translation of a user’s query to selected information sources, and wrap obtained results are detailed Discussion: Current implementation and wrapping perspectives are discussed in terms of integration and interoperability of health information resources.