The PIERCE (Prototyping Informatics and Evaluation for Research in the Clinical Environment) is designed for the Québec, Canada Cardiology Network to enable a single working informatics environment to collect high quality patient and laboratory data within clinical, clinical research and clinical trial protocols, to enable secure data sharing and also sophisticated project tracking and data analysis. This paper describes the implementation of the PIERCE program to support clinical research into triglyceride disorders, an important risk factor for atheromatous heart disease with a strong genetic predisposition in Québec.