Organization of hospital information systems that are currently in use is characterized by a multitude of simple, unfortunately less integrated components. For the integration of the already available as well as new components into a hospital information system, the “Comitee European de Normalisation” (CEN) proposed a basic “Conceptual Architectural Framework”. Based on the CEN proposal, in this paper we present first results of a case study in order to investigate the usability of the Distributed Healthcare Environment (DHE), as a standard architecture for hospital information systems. Another aim of this case study was to design an Order Entry and Result Reporting System and implement it by using DHE.