The cardiovascular reactivation to a recently described videogame task i.e. a maze test was evaluated in the frequency-domain using finger blood pressure (BP) measurement in 27 untreated subjects including 5 mild hypertensives. Age ranged from 23 to 52. BP was measured with a Finapres device. Breathing was analyzed by respiratory inductance plethysmography with a Respitrace. The test consisted of a series of video displayed mazes which had to be solved within short periods of time. The recording session was divided into resting, test and recovery periods. A detrending procedure was applied to each recording prior to the fast Fourier transform (FFT), using a moving average over 20 sec. The mid-frequency (MF, 0.1 Hz) component was increased during the test for SBP and HR as well. Since a large variability was observed between individuals, we calculated the relative changes for this MF component. Increases of 33 % and 54 % in the SBP and HR MF components were observed. These MF changes could depend on the autonomic activation occuring during the performance of the mental task. In addition, the test determined a reduction of the absolute systolic BP (SBP) and heart rate (HR) high-frequency (HF, respiratory-linked) components. However these changes were associated with a modified breathing pattern characterized by a moderate tachypnea and a reduced breathing amplitude (−14%). A statistical adjustment of HF components for breathing amplitude was used to test whether changes in these HF components were due to respiration or to specific mechanisms. Therefore, the relative changes in the SBP or HR HF components were divided by the relative changes in the respiratory amplitude. This procedure demonstrated the SBP or HR HF changes during stress were entirely due to respiration since no significant changes in the normalized indices were detected during the test. This study demonstrates the applicability of this new paradigm to induce cardiovascular reactivity.