The paper gives a brief summary of the SEISMED project and the particular role played by the Reference Centres. Details are given of the hardware and application systems in use in the Royal Hospitals (NHS) Trust (RHT), one of the SEISMED Reference Centres. It proposes, without verification, a definition of a “Security Culture based on three criteria. These are suggested to be the “Awareness” the “Acceptance” and the “Actions” of the management and staff to improve Information Systems Security throughout the RHT. The way that “Awareness” was increased is shown by the specific initiatives commenced as a result of a CRAMM Risk Analysis and the management and staff training programmes. The specific initiatives mentioned include, an Information Systems Security Policy, a contingency and disaster recovery plan, improvements in the physical protection of equipment and changes to the method of access control. The “Acceptance” by the staff of theses measures is considered and the success or failure of “Developing A Security Culture” examined. The role of SEISMED in this process is assessed.