There is a widespread expectation regarding future increased productivity within Health Care, with more and better services to be provided with better resource management. In some distinct clinical areas, knowledge based systems have proven the ability to improve the quality of health care services. Based on our experience, this paper proposes the collaboration between groups with clinical and technical expertise that will lead to the development of viable medical KBSs, whose main features are discussed and that will be integrated in the medical telematic infrastructure as integral parts of an electronic patient record.