This chapter continues to trace the flow of information through the Five Zone Telehomecare model by considering Zone 3—the Dispatcher; Zone 4—the Responders; and Zone 5—the Informatics. Emphasis is placed on the need for each of these three Zones to have a company with a viable business plan and appropriate infrastructure in place in order to function properly and move the information to the next Zone. In addition, the vital role played by carefully crafted and continuously updated protocols is discussed, as well as the challenges facing the integration of all Five Zones and possible solutions to overcoming the challenges.