This introduction outlines the Five Zone Model of Telehomecare presented by the editors as a more accurate depiction of Telehomecare than other models and rubrics found in the literature. The authors show how the tracking of the flow of information through the Five Zones allows for the barriers and challenges faced by care organizations and businesses in their attempt to develop and implement Telehomecare applications to be clearly seen. A definitional rubric that places Telehomecare within the framework of other health care technologies is presented and discussed. Additionally, the organizing principles of the volume are presented and the major themes outlined.