Little can be found in the literature about the applicability of field study methods, particularly contextual inquiry, in the health informatics field. This paper aims to inform and promote the use of contextual inquiry for user-oriented design of clinical information technology (IT) systems. The paper describes how the method was applied in two empirical studies to gather data about end-users' needs, as well as the use and usability of dictation solutions and electronic nursing documentation systems from the viewpoint of their end-users' in real working surroundings. Experience indicates that, compared to typical usability evaluation methods, contextual inquiry may provide valuable support for user-centred design activities: the method is suitable for increasing researchers' understanding of clinical practices, contexts of work, and end-users' interaction with numerous IT systems. However, in clinical settings there are special challenges related to recording and privacy issues, a wide variety of clinical practices and contexts of technology usage, as well as the hectic nature of clinical work.