Mental health care represents over a third of the cost of health care to all EU nations and in US is estimated to be around the 2'5% of the gross national product. It additionally results in further costs to the economy in lost productivity. Depression and Stress related disorders are the most common mental illnesses and the prevention of depression and suicide is one of the 5 central focus points in the European Pact for Mental Health and Well Being. While other mental illnesses may benefit in the long term, Depression and Stress will be the focal point mental illnesses mentioned in OPTIMI. Currently the main treatments for mental illness are pharmacological and evidence based Cognitive Behavioral Therapy (CBT). CBT comprises a set of therapist and patient processes whose format allows for the whole treatment process to be computerized and personalized, Computerised CBT (CCBT). OPTIMI will try to improve the state of the art by monitoring stress and poor coping behavior in high risk population, and by developing tools to perform prediction through early identification of the onset of depression. The main goal of OPTIMI is to improve CCBT programs in order to enhance both efficacy and therapeutic effectiveness. The presentation will outline the main goals the project is aiming and its clinical rationale.