e-Health projects are being implemented globally in low-income countries as a response to the identified inequality and inequity of access to health services for poor populations with a great burden of disease. These projects are seen to offer solutions that provide quality care at a low cost. Limited research is done on the sustainability of these projects. Even less addresses the socio-cultural impact on the host communities. Based on experience of living with a remote community in Ghana, this paper explores the needs of one community, and how e-Health has the ability to meet those needs using different solutions. Also examined are the potential positive and negative impacts that e-Health might yield on the people and their surroundings were e-health solutions to be introduced.