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Recent advances in the study of candidate genes for Adolescent Idiopathic Scoliosis
K. Fendri, S. Patten, C. Zaouter, S. Parent, G. Kaufman, H. Labelle, P. Edery, F. Moldovan
3 - 7
10.3233/978-1-60750-573-0-3
Studies in Health Technology and Informatics
Volume 158: Research into Spinal Deformities 7
Abstract

We used a microarray approach to evaluate gene expression profiles in human AIS osteoblasts, and to identify genes that are differentially expressed following estrogen exposure in non-AIS and AIS human osteoblasts. We found that more than one gene is likely responsible for AIS. Furthermore, some of these genes are estrogen-regulated, suggesting a possible role of estrogens in the etiology of scoliosis.

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