This paper discusses two approaches to “the sociotechnical”, one coming from the Tavistock tradition and the other from actor network theory. These two differ in important ways and from the latter it follows that what patient safety means must be scrutinized and unpacked. The paper thus rudimentarily discusses central contributions to the problematization of patient safety. Last, it is argued that patient safety does not exist apart from the sociotechnical practices that seek to accomplish it, but is constructed in and through them, which is why it is pertinent to reflect on how those practices constructs what comes to qualify as patient safety.