Game controllers for persons with progressive muscular dystrophy have recently been developed. This controller is for the users who cannot press the command buttons on the standard video game controllers. When the user selects the command from the virtual controller on the personal computer by using the mouse, the controller operates the video game controller for the user. This controller consists of the user interface software which works on the PC as a virtual game controller and a signal control unit which emulates pressing buttons of the video game controller electrically. The game controller we developed is now in use and we have received positive feedback