Rehabilitation is placing increasing emphasis on the construct of empowerment as the final goal of any treatment approach. This reflects a shift in focus from deficits and dependence to assets and independence. According to this approach, rehabilitation should aim to improve the quality of the life of the individual by means of effective support to his/her activity and interaction. Here we suggest that advanced technologies can play a significant role in this process. By enhancing the experienced level of “Presence” - the non-mediated perception of successfully transforming intentions into action - these emerging technologies can foster optimal experiences (Flow) and support the empowerment process. Finally, we describe the “NeuroVR” system (http://www.neurovr.org) as an example of how advanced technologies can be used to support Presence and Flow in the rehabilitation process.