Introduction: Approximately 155, 000 Canadians depend on manual wheelchairs for locomotion  and an estimated 31-73% of these people will experience shoulder pain as a result of manual wheeling . Biomechanical research into the determinants of shoulder pain has been inconclusive. However, to date there has been very little research into the neural control of manual wheeling. One concept is that rhythmic upper limb movement (such as arm swing, swimming, and possibly manual wheeling) is regulated by a central pattern generator (CPG) and follows a similar pattern of sensory processing as described for walking. This study will explore this concept by investigating the modulation of cutaneous reflexes during manual wheeling. Purpose: The purposes of this study are to determine if the cutaneous reflex response to stimulation of the superficial radial nerve are phase-dependent during manual wheeling, to determine if there is evidence of task specificity between manual wheeling and upper arm cycling and to determine if manual wheeling experience changes the pattern of reflex modulation during wheeling. Methods: Subjects will include 15 manual wheelchair users (MWUs) with spinal cord injury and 15 non-MWUs. All subjects will complete two tasks in a randomized order including wheeling on a wheelchair treadmill at a self-selected speed and arm cycling using an arm ergometer. Electrical stimulation of the superficial radial nerve will be conducted pseudorandomly throughout the wheeling cycle eliciting cutaneous reflex responses. EMG responses will be measured in 6 muscles. The wheeling cycle will be broken up into phases using a custom made program utilizing SmartWheel and Optotrak data. Cutaneous reflex responses will be grouped and averaged depending on the phase of the wheeling cycle and be compared between MWUs and non-MWUs. Anticipated Results: It is anticipated that that the difference in cutaneous reflex amplitude between stimulated and un-stimulated EMG responses will vary dependending on the phase of the wheeling cycle. It is also anticipated that task-dependency will be evident by greater amounts of cutaneous reflex modulation of the wheeling task compared to the arm cycling task and that a greater amount of modulation will be observed in the MWU group compared to the non-MWU group.