This chapter will discuss the ongoing development and integration of micro and nano technologies within the Tyndall National Institute that will enable the future vision of ambient intelligence with specific application to the area of personalised health (P-Health). Ambient Intelligent Systems open entirely new possibilities for future applications and resultant markets. Ultimately, these systems will create intelligent environments that cater continuously for the requirements of the individual in everyday life and apply it in a totally coherent manner. They will learn and evolve to anticipate user-requirements. We will discuss ongoing research in the areas of sensors, sensor interfacing, interconnection and packaging, hardware platforms, infrastructure and power delivery for ambient systems with applications in the p-health domain.