Grid technology can provide medical organisations with powerful tools through which they can gain coordinated access to computational resources that hitherto where inaccessible to them. This paper discusses how several classes of medical applications could benefit from the use of Grid technology. We concentrate on applications that were put forward by partners in the Dutch VL‐e project. After describing the difficulties related to the realization of such applications without making use of the Grid, we describe an architecture that allows the applications to use Grid resources. We demonstrate how this architecture can be integrated into existing systems to provide flexible and transparent access to Grid services and show performance results of a test case.