Clinical and medical knowledge evolve and this causes changes in concepts and terms that describe them. The objective of this work is to formally present an ontology-based standard architecture that will be used in the scenario of neurodegeneration research to maintain terminologies and their relations updated and coherent over the time. The proposed structure is composed by three elements that will allow the user to do a list of operations on the terminology resources explicitly contemplated by the Common Terminology Service Release 2 (CTS2).
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