Medical research and clinical practice deal with complex and heterogeneous data. This requires a systematic approach for semantic integration of information to support clinicians in their daily tasks.

As the clinicians speak and think in a very different language than that of the computer scientists, existing knowledge engineering approaches based on classical expert interviews fall short. Moreover, as human health is a very sensitive subject, the reuse of standardized hence reliable ontologies as medical knowledge resources becomes a key requirement.

In this paper, we first discuss the specific medical knowledge engineering requirements, we identified along a semantic medical image and text retrieval use case. Then we report on ongoing work towards establishing a corresponding methodology based on ontology reuse that is derived from the requirements. The methodology, which will be discussed in detail, relies on a novel technique for semi-automatically generating a set of potential user queries to support the knowledge elicitation process.