Cyclodextrins(CDs) form stable supramolecular structures (polypseudorotaxanes) with different polymers, through a threading process, by hosting the hydrophobic chain in their free cavities.

The kinetics of formation of such adducts in different solvents and with different reactants (α-, β-, or γ-CD, and PEG, PPG or pluronics) at different temperatures was studied. The physico-chemical treatment provides the number of CD molecules threaded per single polymer chain, and the corresponding thermodynamic parameters. Addition of salts to the reaction medium reveal a Hofmeister series effect. Induced water structure changes were observed when D₂O, urea and sugars were added to the solvent.