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Co-crystallization of Carbamazepine and Isonicotinamide: Two New Co-crystal Forms?
J.H. ter Horst, P.W. Cains, G.M. van Rosmalen
143 - 150
BIWIC 2007
Abstract

Co-crystals of Carbamazepine and Isonicotinamide form through a solvent mediated transformation process when a dry mixture of the pure crystalline components is suspended in ethanol. First, needle-like crystals grow while the pure crystalline components dissolve. Eventually plate-like crystals grow at the expense of the needle-like crystals. We are confident that both the needle-like and the plate-like crystals are co-crystal forms of Carbamazepine and Isonicotinamide.

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