Today, most universities have enhanced their classroom courses with online learning systems. However, studies still find organizational systems with specific low usage, compared with the large population within the universities. In order to suggest effective institutional implementation strategies in e-learning system deployment, a validated model framework is applied to a local private tertiary institution. 507 respondents (students) completed an online survey during the second year of the system deployment. Significant correlations were found for performance expectancy, effort expectancy, social influence, and facilitating conditions, in predicting and explaining intention to use of the system. Age and voluntariness were found significant moderator to the determinants; while gender and computer experience were found non-significant in the model. Based on the results, implementation strategies, including institutional issues, management issues, technological issues, pedagogical issues, ethical issues, interface design issues, resource support issues, and evaluation issues were discussed. Limitations and further research agenda were also suggested.