This study explores the perception and views of healthcare professionals in the subcontinent (India and Pakistan) towards the wireless handheld technology in the healthcare setting. A mixed methodology was adopted to explore the determinants of the wireless handheld devices in the healthcare setting. Interviews were conducted with 30 healthcare professionals to explore the initial themes. This was followed up with a survey instrument, specifically developed for this study, and distributed to 300 healthcare professionals in Pakistan and India. 200 useable surveys from India and 97 from Pakistan were received. The results of the study indicate that healthcare professionals felt that to use the wireless technology, the integration of the clinical and operational process is essential. Factor analysis through SPSS showed that any development of technological solutions for handheld devices would benefit, by considering the clinical, technological, and operational influences of the wireless technology in addition to clinical influences, clinical preference, training, and technical support. The study culminated in the development of an initial conceptual framework. The scope of this study is restricted to wireless handheld devices such as the smart phones, handheld PCs and PDAs.