The paper describes the results of an e-learning experimental project for Continuous Medical Education (CME) in Occupational Medicine in terms of: extent of the e-learning courses usage by the healthcare personnel, knowledge acquisition and satisfaction. 11 courses have been available for 11 months during which 2,034users all over Italy enrolled in5,183 courses with a success percentage of 72% and a significant difference between test scores performed before and after attending the e-learning courses. Also user's satisfaction, inspected through a questionnaire, has provided good results. Starting from the experience reported, the authors are confident that e-learning will gain ground and evolve as an effective and appreciated educational mean for CME.