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The American Nurses Association published the third iteration of its nursing informatics scope and standards of practice in 2008. This work reflects the significant evolution of the specialty from the original scope of practice statement published in 1994 and the first nursing informatics standards of practice in 1995. Although the definition of nursing informatics remains essentially unchanged from that presented in 2001, the inclusion of “wisdom” reflects today's emerging mandate for evidence-based practice and decision support resources for the knowledge worker.