An aging population and an increase in chronically ill patients demand teamwork treatment models. To support these with information systems, interoperability is a prerequisite. Model-driven software development (MDSD) with special healthcare extensions can enable reuse of components and improve conformance to international standards. In this paper, a MDSD HealthCare Framework is proposed and demonstrated for homecare services. Using the framework, information systems will improve their conformance to international standards and the interoperability with other systems.