As research interests in telehealth applications increase, traditional behavioral instruments need to be adapted for use for new mediums in telehealth evaluation. Display and method of presentation changes can affect the reliability and occasionally the validity of the revised instruments. This paper explores critical concerns to be addressed with electronic conversion of psychometric instruments and provides an example of testing methodology and psychometric properties for an instrument measuring quality of life (CQLI) converted in electronic format for use within a telehealth intervention.