Quality of life (QoL) is a key outcome in clinical research. New electronic tools enable high-frequent collection of QoL. To make QoL data available for the treatment process, integration into Electronic Health Record (EHR) systems is needed. Transferring QoL data from a patient smartphone on the Internet into the protected EHR system is challenging from an information security perspective. Our proof-of-concept demonstrates technical and clinical feasibility of this approach.