This study introduces a Generative Artificial Intelligence (GenAI) assistant designed to address key challenges in Remote Patient Monitoring (RPM) for hypertension. After a comprehensive needs assessment from clinicians and patients, we identified pivotal issues in RPM data management and patient engagement. The GenAI RPM assistant integrates a patient-facing chatbot, clinician-facing smart summaries, and automated draft portal messages to enhance communication and streamline data review. Validated through six rounds of testing and evaluations by ten participants, the initial prototype was positively received, highlighting the importance of personalized interactions. Our findings demonstrate GenAI’s potential to improve RPM by optimizing data management and enhancing patient-provider communication.