Biobanks serve as vital repositories for human biospecimens and clinical data, promoting biomedical and clinical research. The integration of electronic health records particularly enhances research opportunities in the era of genomics and personalized medicine, improving understanding of tumor development and disease progression. Based on the Korea Biobank Network Common Data Model, it is possible to expand data collection across various diseases. We have developed an innovative big data platform designed to efficiently collect large-scale clinical information within the KBN. By implementing the system structure, data quality management processes, and basic statistical preprocessing functionalities, we have collected data from 136,473 individuals from 2021 to 2023, demonstrating the platform’s continuous and efficient data collection capabilities. Integration with hospital systems and robust quality management ensure the acquisition of high-quality data.