This study evaluates the impact of Clinical Decision Support System (CDSS) integration into the Nursing Information System 2.0 on nursing records and nurse satisfaction. Longitudinal data collection employs questionnaires and nursing records audits. Findings show improved electronic signature integration and nursing problem identification, benefiting real-time patient information access and record completeness. Younger, less experienced, highly educated nurses exhibit higher CDSS usage and acceptance. Overall, 80.2% agreement rate confirms CDSS’s positive impact, highlighting the importance of user effectiveness evaluation in system implementation for nursing innovation.