The healthcare system is increasingly being digitized. Besides expected benefits, the transformation can negatively affect nurses with increasing technostress. This study aimed to examine technostress among nurses and its association with job satisfaction. Cross-sectional survey data of 154 nurses working in acute hospitals in Switzerland was analyzed using Welch’s ANOVA with the Games-Howell test and multiple linear regression model. Among the technostress dimensions, uncertainty was the most agreed upon by nurses, with a mean score of 2.21 (on a scale ranging from 0 to 4), and it differed significantly from other technostress dimensions. The multiple linear regression showed that the feeling of invasion of private life had the strongest negative association with job satisfaction (β = -0.34). Nurses experience constant changes or new developments in the technologies in their organization. Therefore, health organizations should carefully plan their digital transformation processes to minimize simultaneous technology implementations and allow adaptation time.