The potential for technology to transform health care is tremendous, but advances in digital health may also bring privacy and data security challenges that may exacerbate inequalities. Hence, it is critical that the development of digital health is included in a framework of humanistic and ethical values. France drew up its roadmap for accelerating the shift towards digital health with ethics at the forefront, along with security and interoperability pillars. Criteria such as digital health for all, transparency of data processing, trustworthy AI, and eco-responsibility and sustainability of digital health were elaborated. Under the French Presidency of the Council of the European Union, building on the proposal of ethical criteria from France, eHealth network representatives unanimously adopted 16 European ethical principles for digital health, formalizing trust commitments towards European citizens and paving the way for the European Health Data Space.