In recent years, Greece has made efforts towards digital transformation. The most significant was the installation and use of eHealth systems and applications by health professionals. The purpose of this study is to investigate the views of physicians on the usefulness, ease of use and user satisfaction of the eHealth applications and especially the e-prescription system. Data were collected by using a 5-point Likert-scale questionnaire. The study indicated that the usefulness, ease of use and user satisfaction of eHealth applications: a)are rated at moderate levels and b) are not affected by characteristics such as gender, age, education, years of practicing the medical profession, the type of medical practice and the use of different electronic applications.