Improving access to health information and territorial resources can be a way to help strengthen health-related quality of life perception in disadvantaged communities. We argue that, in countries facing diverse economic and social disparities and challenges, technology can be leveraged to improve communities’ access to evidence-based, up-to-date, comprehensive, and culturally appropriate supportive territorial resources, thereby improving individuals’ quality of life, especially for those living with one or more chronic diseases. This paper discusses the benefits of introducing and designing a user-friendly, relevant, and effective web-based technology to broaden patients’ access to healthcare resources and tailored health information, supporting community-based quality of life transformation.