Current healthcare industries are more focusing on quality, efficiency, and safety. Nursing information systems are among the key components of healthcare information systems; they can help nurses to use data more effectively while managing their nursing activities, allowing them to improve patient care and develop their knowledge. According to clinical various needs and various hospitals, so as to develop a flexible Nursing Information System, this study based on the MVC, Object-Oriented Programming is used to develop the web interface, and web service is used to exchange data with HIS. This design and implements a flexible Nursing Information System which is applied and summarized clinically on the function of acquiring clinical data from the different clinical requirements and showing the web pages and different kinds of forms from the device browser. Under the software development environment of high variability, high complexity, and high customization in the medical industry, a scalable and maintainable nursing information system is realized through the MVC architecture and the Master-Detail data table design, which can meet the needs of different organizations.