Nursing interruptions can suspend the nursing process and distracting the nurses’ attention. In a nursing information system, there are lots of pop-up windows to notify the nurses to complete the nursing records. These notifications can also interrupt the original work. We proposed an “Integrated Reminders of Nursing Written Assignment” system to reduce the number of interruptions from the nursing information system. The result showed that the number of pop-up windows decreased from 489.48 to 0 per shift. The completeness of the nursing records raised from 97.3% to 100%. The “Integrated Reminders of Nursing Written Assignment” can effectively reduce the frequency of nursing interruptions and improve the quality of nursing records.