The digital transformation of education is an important trend of the current education development. Through the introduction of digital technology and tools, it promotes the reform of education and teaching and improves the quality and effect of education. In the context of the digital transformation of regional education, classroom teaching also needs to carry out corresponding changes to adapt to the new educational environment, improve the quality of education, and promote the all-round development of students. Based on this, starting from the background of digital transformation of regional education, this paper builds the classroom teaching mode of mixed research and study, drives the reform of education and teaching, explores the development path of digital literacy of teachers and students, in order to provide program reference and case reference for regional classroom teaching reform, and realize the balance of education.