During the epidemic, college students are prone to anxiety and depression, and long-term anxiety and depression will lead to a decline in resistance. There are a lot of bacteria in the office environment that college students use daily, and college students with low resistance become vulnerable groups. In this article, we introduce the Guard Dog, a sterilizer that embeds UV disinfection protection into the office environment to sterilize personal contact items for college students in their daily work and study. In this preliminary study, the aim was to explore suitable interaction designs that provide opportunities for technology to be embedded in the existing college student office environment. Preliminary results show the importance of IoT in the daily interactions of college students. Students participating in the trial validate the flexibility of digital protection. Finally, we discuss that these daily activities enhance student protection, which demonstrates an opportunity to build personal sanitization protection between college students and the office environment.