Under the background of “New Engineering Course”, aiming at the difficulty and lack of project resources in the practice course of “Introduction to Artificial Intelligence”, the project design of practice course of Introduction to Artificial Intelligence based on K210 chip is proposed. Based on Python language, practical projects are designed with K210 chip to be applied to the introductory course of Artificial Intelligence. The results show that the students’ final grades are improved and their interest and enthusiasm are increased through practical courses. The design of AI practical course based on K210 can provide reference for this course and other interdisciplinary introductory courses.