We are in the era of big data, and it is particularly important to cultivate students’ data processing ability. Python is an important auxiliary tool for data analysis, and its syntax is concise and clear, which is suitable for junior high school students to start learning code language. Making full use of modern information technology and Innovating Curriculum form is the new requirement of “China education modernization 2035”. Integrating Python into junior high school mathematics classroom is not only the innovation of mathematics curriculum form, but also a good way to cultivate students’ thinking ability and programming thought. Based on the understanding of Python software and data processing plate in junior high school mathematics curriculum, this paper analyzes the promotion of students’ thinking ability by integrating Python into junior high school mathematics classroom, and explores the strategies of applying Python in teaching combined with cases.